To begin a patient’s PDX testing or chemosensitivity xenograft testing the physician supplies Altogen Labs with a piece of resected living tumor, or biopsy (please contact firstname.lastname@example.org for a formal quote and list of required documents). Please note that it takes 2-3 months and at least $19,995 USD to complete standard PDX or chemosensitivity xenograft testing.
To learn more about xenotransplantation method please visit the xenograft science webpage.
Xenotransplantation research applications are described at our xenograft applications resource.
To learn more about in vivo xenograft testing services, please visit our services webpage.
Available PDX models and standard PDX protocols are described at our PDX Models resource.
Standard 3-Step Xenograft Testing Process:
- Tumor tissues are implanted into multiple recipient immunocompromised mice and allowed to grow. Alternatively, the biopsy tissue is processed and cancer cell culture expanded and transformed (if necessary) to initiate xenotransplantation study.
- While tumor implant is growing, the patient should perform standard clinical tests and treatments as advised by physician. The patient’s physician will define the best xenograft testing strategy (PDX xenograft study, chemosensitivity tests, etc). Altogen Labs also offers a number of cancer characterization services, including protein (ELISA, WES, Western Blot) and mRNA expression (RT-PCR) analysis, biomarker expression and oncogene mutation analysis, IC50 assays, tumor cells drug response and resistance, as well as other types of tumor biology characterization and molecular analysis.
- During the xenograft study progression, our scientists will report study results as they become available to help physician in modifying treatment strategy as soon as possible. PDX and chemosensitivity testing will provide the patients with data as it become available to achieve best cancer treatment results via personalized therapy approach.